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对于第二个问题，这项研究得出了更加有趣而大胆的结论：轴突形态可能会直接调节动作电位的传导速度。当研究团队去除了神经元膜上的胆固醇后，小鼠轴突的珍珠状结构减少了，轴突传导动作电位的速度也随之减慢。研究指出，由于胆固醇具有多重作用，因此轴突形态可能不是唯一的贡献因素，但这项研究还是提出了一种全新的神经元可塑性范式：生物物理因素的调节影响轴突纳米珍珠化，从而控制动作电位传导速度。
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这一爆炸性的研究一经发表，立刻引起了学术界的热议。在《科学》网站今日的报道中，多位神经科学家发表了自己对该研究的观点。一些学者认为该研究意义重大，但也有观点质疑这项研究的样本处理方法，认为珍珠状结构可能并非源于轴突本身的结构，而是快速冷冻制备过程的产物。
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需要指出的是，对于轴突的珍珠状，科学家们其实并不陌生。早在半个世纪前，就有研究发现在遭受神经系统疾病或是面临压力时，轴突会收缩成珍珠状，这样的改变可以避免细胞损伤的扩散。此外，即使是正常神经元的轴突，在细胞核物质运输进出受阻时，也可以暂时膨大形成囊泡。但不同的是，这些“珍珠”都属于宏观尺度；而在最新研究中，以纳米尺度均匀分布的“珍珠串”是首次发现，并且是正常神经元轴突所共有的。
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